Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers.

Rust, C; Bauchmuller, K; Bernt, C; Vennegeerts, T; Fickert, P; Fuchsbichler, A; Beuers, U

Rust, C; Bauchmuller, K; Bernt, C; Vennegeerts, T; Fickert, P; Fuchsbichler, A; Beuers, U.

Affiliation

Rust C; Department of Medicine II-Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany. christian.rust@med.uni-muenchen.de

Gut ; 55(5): 719-27, 2006 May.

Article in En | MEDLINE | ID: mdl-16322111

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Glycochenodeoxycholic Acid/pharmacology; Hepatocytes/pathology; Sulfasalazine/pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal/metabolism; Apoptosis/drug effects; Caspase 3; Caspase 9; Caspases/metabolism; Cell Line, Tumor; Depression, Chemical; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Hepatocytes/drug effects; Hepatocytes/metabolism; Humans; Liver/drug effects; Liver/metabolism; Liver/pathology; Male; Mesalamine/pharmacology; NF-kappa B/metabolism; Perfusion; Rats; Rats, Sprague-Dawley; Sulfapyridine/pharmacology; Sulfasalazine/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfasalazine / Anti-Inflammatory Agents, Non-Steroidal / Hepatocytes / Glycochenodeoxycholic Acid Limits: Animals / Humans / Male Language: En Journal: Gut Year: 2006 Document type: Article Affiliation country: Germany

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