Elevated levels of serum perforin in chronic HIV-1 and acute SIV/SHIV infection.
AIDS
; 20(1): 125-7, 2006 Jan 02.
Article
in En
| MEDLINE
| ID: mdl-16327331
ABSTRACT
The impaired functional activity of cytotoxic T lymphocytes and natural killer cells during HIV-1 infection has recently been attributed to decreased intracellular levels of perforin and granzyme B. In sera from individuals chronically infected with HIV-1 we report increased levels of extracellular perforin compared with uninfected individuals. Increased perforin was also observed during experimental SIV/SHIV infection. The combination of reduced intracellular perforin levels and an increased serum level indicates that HIV infection induces aberrant perforin secretion.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Membrane Glycoproteins
/
HIV Infections
/
Simian Acquired Immunodeficiency Syndrome
/
HIV-1
/
Simian Immunodeficiency Virus
Limits:
Animals
/
Humans
Language:
En
Journal:
AIDS
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
2006
Document type:
Article
Affiliation country:
Sweden