Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions.

Józsi, Mihály; Heinen, Stefan; Hartmann, Andrea; Ostrowicz, Clemens W; Hälbich, Steffi; Richter, Heiko; Kunert, Anja; Licht, Christoph; Saunders, Rebecca E; Perkins, Stephen J; Zipfel, Peter F; Skerka, Christine

Józsi, Mihály; Heinen, Stefan; Hartmann, Andrea; Ostrowicz, Clemens W; Hälbich, Steffi; Richter, Heiko; Kunert, Anja; Licht, Christoph; Saunders, Rebecca E; Perkins, Stephen J; Zipfel, Peter F; Skerka, Christine.

Affiliation

Józsi M; Department of Infection Biology, Leibniz Institute for Natural Product Research, and Infection Biology, Beutenbergstrasse 11a, 07745 Jena, Germany.

J Am Soc Nephrol ; 17(1): 170-7, 2006 Jan.

Article in En | MEDLINE | ID: mdl-16338962

Subject(s)

Complement Factor H/genetics; Hemolytic-Uremic Syndrome/genetics; Mutation; Amino Acid Sequence; Animals; Cells, Cultured; Complement C3b/metabolism; Complement C3d/metabolism; Complement Factor H/chemistry; Complement Factor H/physiology; Endothelial Cells/metabolism; Heparin/metabolism; Models, Molecular; Molecular Sequence Data; Spodoptera

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Collection: 01-internacional Database: MEDLINE Main subject: Complement Factor H / Hemolytic-Uremic Syndrome / Mutation Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Am Soc Nephrol Journal subject: NEFROLOGIA Year: 2006 Document type: Article Affiliation country: Germany Country of publication: United States

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