N-Glycosyl-thiophene-2-carboxamides: effects on endothelial cell growth in the presence and absence of bFGF--a significant increase in potency using per-O-acetylated sugar analogues.

Rawe, Sarah L; Zaric, Violeta; O'Boyle, Kathy M; Murphy, Paul V

Rawe, Sarah L; Zaric, Violeta; O'Boyle, Kathy M; Murphy, Paul V.

Affiliation

Rawe SL; Centre for Synthesis and Chemical Biology, UCD School of Chemistry and Chemical Biology, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.

Bioorg Med Chem Lett ; 16(5): 1316-9, 2006 Mar 01.

Article in En | MEDLINE | ID: mdl-16343897

Subject(s)

Amides/chemistry; Amides/pharmacology; Carbohydrates/chemistry; Endothelial Cells/cytology; Endothelial Cells/drug effects; Fibroblast Growth Factor 2/pharmacology; Thiophenes/chemistry; Acetylation; Amides/chemical synthesis; Animals; Cattle; Cell Proliferation/drug effects; Cells, Cultured; Glycosylation; Molecular Structure

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Collection: 01-internacional Database: MEDLINE Main subject: Thiophenes / Carbohydrates / Fibroblast Growth Factor 2 / Endothelial Cells / Amides Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Document type: Article Affiliation country: Ireland Country of publication: United kingdom

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