Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfa1 binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. 2002.

Chikazu, Daichi; Li, Xiaodong; Kawaguchi, Hiroshi; Sakuma, Yoko; Voznesensky, Olga S; Adams, Douglas J; Xu, Manshan; Hoshi, Kazuto; Katavic, Vedran; Herschman, Harvey R; Raisz, Lawrence G; Pilbeam, Carol C

Chikazu, Daichi; Li, Xiaodong; Kawaguchi, Hiroshi; Sakuma, Yoko; Voznesensky, Olga S; Adams, Douglas J; Xu, Manshan; Hoshi, Kazuto; Katavic, Vedran; Herschman, Harvey R; Raisz, Lawrence G; Pilbeam, Carol C.

J Bone Miner Res ; 20(10): 1888-98, 2005 Oct.

Article in En | MEDLINE | ID: mdl-16355502

Subject(s)

Bone Morphogenetic Proteins/metabolism; Calcification, Physiologic/physiology; Core Binding Factor Alpha 1 Subunit/metabolism; Cyclooxygenase 2/biosynthesis; Gene Expression Regulation, Enzymologic/physiology; Osteoblasts/enzymology; Transforming Growth Factor beta/metabolism; Animals; Binding Sites/genetics; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins/pharmacology; Calcification, Physiologic/drug effects; Cyclooxygenase 2/deficiency; Cyclooxygenase 2/genetics; Gene Expression Regulation, Enzymologic/drug effects; Mice; Mice, Knockout; Osteoblasts/cytology; Osteogenesis/drug effects; Osteogenesis/physiology; Protein Binding; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; Regulatory Elements, Transcriptional/genetics; Sequence Deletion/genetics; Transforming Growth Factor beta/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Calcification, Physiologic / Gene Expression Regulation, Enzymologic / Transforming Growth Factor beta / Bone Morphogenetic Proteins / Cyclooxygenase 2 / Core Binding Factor Alpha 1 Subunit Limits: Animals Language: En Journal: J Bone Miner Res Journal subject: METABOLISMO / ORTOPEDIA Year: 2005 Document type: Article

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