Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase.
Bioorg Med Chem Lett
; 16(5): 1146-50, 2006 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-16368234
ABSTRACT
Pyrimidino-thiazolyl carbonitriles were prepared that are potent VEGFR-2 (KDR) kinase inhibitors. The modification of lead structures resulted in 3m which exhibited the best overall profile in KDR inhibitory activity, iv/po pharmacokinetics, and reduced hERG affinity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrimidines
/
Thiazoles
/
Vascular Endothelial Growth Factor Receptor-2
/
Protein Kinase Inhibitors
/
Nitriles
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2006
Document type:
Article
Affiliation country:
United States
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM