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V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors.
Grbovic, O M; Basso, A D; Sawai, A; Ye, Q; Friedlander, P; Solit, D; Rosen, N.
Affiliation
  • Grbovic OM; Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Proc Natl Acad Sci U S A ; 103(1): 57-62, 2006 Jan 03.
Article in En | MEDLINE | ID: mdl-16371460
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Chaperonins / Cell Cycle Proteins / Mutation, Missense / Proto-Oncogene Proteins B-raf / Melanoma Limits: Animals / Female / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Chaperonins / Cell Cycle Proteins / Mutation, Missense / Proto-Oncogene Proteins B-raf / Melanoma Limits: Animals / Female / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States