Multiple U2AF65 binding sites within SF3b155: thermodynamic and spectroscopic characterization of protein-protein interactions among pre-mRNA splicing factors.

Thickman, Karen R; Swenson, Matthew C; Kabogo, Joseph M; Gryczynski, Zygmunt; Kielkopf, Clara L

Thickman, Karen R; Swenson, Matthew C; Kabogo, Joseph M; Gryczynski, Zygmunt; Kielkopf, Clara L.

Affiliation

Thickman KR; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

J Mol Biol ; 356(3): 664-83, 2006 Feb 24.

Article in En | MEDLINE | ID: mdl-16376933

Subject(s)

Circular Dichroism; Nuclear Proteins/metabolism; Phosphoproteins/metabolism; Protein Interaction Mapping; RNA Precursors/metabolism; RNA Splicing/physiology; Ribonucleoprotein, U2 Small Nuclear/metabolism; Ribonucleoproteins/metabolism; Thermodynamics; Amino Acid Sequence; Animals; Binding Sites; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Proteins/chemistry; Phosphoproteins/chemistry; Phosphoproteins/genetics; Protein Conformation; Protein Structure, Tertiary; RNA Precursors/chemistry; RNA Splicing Factors; Ribonucleoprotein, U2 Small Nuclear/chemistry; Ribonucleoprotein, U2 Small Nuclear/genetics; Ribonucleoproteins/chemistry; Sequence Homology, Amino Acid; Spectrometry, Fluorescence; Spliceosomes/metabolism; Splicing Factor U2AF; Tryptophan/chemistry; Tryptophan/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Ribonucleoproteins / Thermodynamics / Nuclear Proteins / RNA Precursors / RNA Splicing / Circular Dichroism / Ribonucleoprotein, U2 Small Nuclear / Protein Interaction Mapping Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Mol Biol Year: 2006 Document type: Article Affiliation country: United States

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