Assessment of age-related isoniazid hepatotoxicity during treatment of latent tuberculosis infection.
Curr Med Res Opin
; 22(1): 217-21, 2006 Jan.
Article
in En
| MEDLINE
| ID: mdl-16393447
ABSTRACT
BACKGROUND:
Since the introduction of new recommendations for the treatment of latent tuberculosis infection (LTB1) disregarding age as a limitation, increasing numbers of older individuals are expected to undergo treatment with isoniazid for the prevention of tuberculosis, raising the potential for an increase in isoniazid hepatotoxicity.OBJECTIVE:
To compare the frequency of hepatotoxicity requiring withdrawal of isoniazid therapy for LTB1 in patients under and over 35 years of age, managed according to current practice guidelines.DESIGN:
A retrospective analysis of 300 patients who underwent isoniazid therapy for LTB1 according to a protocol based on the current practice guidelines.SETTING:
Public health clinic of Passaic County, NJMain outcomemeasures:
The frequency of symptomatic isoniazid hepatitis in various age groups.RESULTS:
Of 165 patients < 35 years of age, 3(2%) patients developed hepatitis (AST > 3 times the upper limit of normal). Of 135 patients > or = 35 years of age, 4(3%) patients developed hepatitis. Statistical comparison between the two groups failed to show a significant difference (p = 0.705).CONCLUSIONS:
No difference was detected in the frequency of isoniazid hepatotoxicity between patients < 35 and > or = 35 years of age. Clinically monitored isoniazid therapy of LTB1 patients > or = 35 years of age may not predispose subjects to an increased risk of hepatotoxicity. Limitations of this work include the small sample size and the retrospective nature of the study.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tuberculosis
/
Chemical and Drug Induced Liver Injury
/
Isoniazid
/
Liver
/
Antitubercular Agents
Type of study:
Guideline
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Curr Med Res Opin
Year:
2006
Document type:
Article
Affiliation country:
United States