Refining the effects observed in a developmental neurobehavioral study of ammonium perchlorate administered orally in drinking water to rats. I. Thyroid and reproductive effects.

York, Raymond G; Lewis, Elise; Brown, W Ray; Girard, Michael F; Mattie, David R; Funk, Kathleen A; Strawson, Joan S

York, Raymond G; Lewis, Elise; Brown, W Ray; Girard, Michael F; Mattie, David R; Funk, Kathleen A; Strawson, Joan S.

Affiliation

York RG; Charles River Laboratories, Preclinical Services, 905 Sheehy Drive, Horsham, PA 19044, USA. raymond.york@us.crl.com

Int J Toxicol ; 24(6): 403-18, 2005.

Article in En | MEDLINE | ID: mdl-16393933

Subject(s)

Perchlorates/toxicity; Prenatal Exposure Delayed Effects; Quaternary Ammonium Compounds/toxicity; Reproduction/drug effects; Thyroid Gland/drug effects; Water Pollutants, Chemical/toxicity; Administration, Oral; Animals; Animals, Newborn; Behavior, Animal/drug effects; Brain/drug effects; Brain/growth & development; Dose-Response Relationship, Drug; Female; Lactation; Male; Maternal Exposure; No-Observed-Adverse-Effect Level; Organ Size/drug effects; Perchlorates/administration & dosage; Pregnancy; Quaternary Ammonium Compounds/administration & dosage; Rats; Rats, Sprague-Dawley; Thyroid Gland/growth & development; Thyroid Gland/pathology; Thyrotropin/blood; Thyroxine/blood; Triiodothyronine/blood; Water Pollutants, Chemical/administration & dosage

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Collection: 01-internacional Database: MEDLINE Main subject: Prenatal Exposure Delayed Effects / Reproduction / Thyroid Gland / Water Pollutants, Chemical / Perchlorates / Quaternary Ammonium Compounds Limits: Animals / Pregnancy Language: En Journal: Int J Toxicol Journal subject: TOXICOLOGIA Year: 2005 Document type: Article Affiliation country: United States Country of publication: United States

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