Epigallocatechin-3-gallate delivers hydrogen peroxide to induce death of ovarian cancer cells and enhances their cisplatin susceptibility.

Chan, Marion M; Soprano, Kenneth J; Weinstein, Kate; Fong, Dunne

Chan, Marion M; Soprano, Kenneth J; Weinstein, Kate; Fong, Dunne.

Affiliation

Chan MM; Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA. marion.chan@temple.edu

J Cell Physiol ; 207(2): 389-96, 2006 May.

Article in En | MEDLINE | ID: mdl-16402374

Subject(s)

Catechin/analogs & derivatives; Cell Proliferation/drug effects; Cisplatin/pharmacology; Hydrogen Peroxide/metabolism; Antineoplastic Agents/pharmacology; Antioxidants/pharmacology; Catechin/pharmacology; Cell Line, Tumor; Cell Survival/drug effects; Cyclic N-Oxides/pharmacology; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Female; Fluoresceins/chemistry; Fluoresceins/metabolism; Humans; Hydrogen Peroxide/pharmacology; Ovarian Neoplasms/drug therapy; Ovarian Neoplasms/metabolism; Ovarian Neoplasms/pathology; Pyruvic Acid/pharmacology; Spin Labels

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Collection: 01-internacional Database: MEDLINE Main subject: Catechin / Cisplatin / Cell Proliferation / Hydrogen Peroxide Limits: Female / Humans Language: En Journal: J Cell Physiol Year: 2006 Document type: Article Affiliation country: United States

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