Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids.

Fyffe, Stewart A; Alphey, Magnus S; Buetow, Lori; Smith, Terry K; Ferguson, Michael A J; Sørensen, Morten D; Björkling, Fredrik; Hunter, William N

Fyffe, Stewart A; Alphey, Magnus S; Buetow, Lori; Smith, Terry K; Ferguson, Michael A J; Sørensen, Morten D; Björkling, Fredrik; Hunter, William N.

Affiliation

Fyffe SA; Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

J Mol Biol ; 356(4): 1005-13, 2006 Mar 03.

Article in En | MEDLINE | ID: mdl-16405912

Subject(s)

Fatty Acids/chemistry; Isoenzymes/chemistry; PPAR delta/chemistry; PPAR-beta/chemistry; Protein Conformation; Recombinant Proteins/chemistry; Crystallography, X-Ray; Enzyme Activation; Fatty Acids/metabolism; Glucans/chemistry; Glucans/metabolism; Humans; Isoenzymes/genetics; Isoenzymes/metabolism; Models, Molecular; Molecular Sequence Data; PPAR delta/genetics; PPAR delta/metabolism; PPAR-beta/genetics; PPAR-beta/metabolism; Recombinant Proteins/genetics; Recombinant Proteins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Protein Conformation / Recombinant Proteins / PPAR-beta / PPAR delta / Fatty Acids / Isoenzymes Limits: Humans Language: En Journal: J Mol Biol Year: 2006 Document type: Article Affiliation country: United kingdom Country of publication: Netherlands

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