The effects of epidural deracoxib on the ground reaction forces in an acute stifle synovitis model.
Vet Surg
; 35(1): 34-42, 2006 Jan.
Article
in En
| MEDLINE
| ID: mdl-16409407
ABSTRACT
OBJECTIVE:
To evaluate the efficacy of epidurally administered deracoxib to mediate the signs of a sodium urate crystal-induced stifle synovitis in dogs, and to compare the efficacy of epidural versus subcutaneously administered deracoxib. STUDYDESIGN:
Experimental, randomized, blinded, placebo-controlled modified cross-over design. ANIMALS Random source, adult, mixed breed dogs (n = 24; 14 males, 10 females).METHODS:
Sodium urate crystals were used to create a stifle synovitis model to evaluate the efficacy of deracoxib. Dogs were divided into 4 groups 3 mg/kg epidural deracoxib, 1.5 mg/kg epidural deracoxib, 3 mg/kg subcutaneous deracoxib, and a placebo (vehicle for deracoxib). Force plate and subjective evaluations were made at time 0, 2, 4, 8, 12, and 24 hours post-treatment. Repeated measures ANOVA with Bonferroni-corrected post hoc comparisons was used to determine significant treatment effects.RESULTS:
Peak vertical force (PVF) and vertical impulse (VI) were both significantly higher in deracoxib treated dogs compared with placebo. For 3 mg/kg epidural and subcutaneous deracoxib, PVF and VI were significantly greater than for 1.5 mg/kg epidural deracoxib. Overall pain score for all deracoxib-treated dogs was significantly lower than for placebo dogs.CONCLUSIONS:
Epidural administration of deracoxib is effective at providing analgesia in an acute joint pain model; however, it does not appear to be more effective than systemic administration. CLINICAL RELEVANCE Injectable deracoxib is effective in providing analgesia in acute inflammatory conditions of synovial joints.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stifle
/
Sulfonamides
/
Synovitis
/
Dog Diseases
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Vet Surg
Year:
2006
Document type:
Article
Affiliation country:
United States