Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): IV. Assessment of the repeated-dose toxicological potential of synthesized L-valyl-L-prolyl-L-proline in male and female rats and dogs.

Nakamura, Yasunori; Bando, Izuki; Mennear, John H; Bernard, Bruce K

Nakamura, Yasunori; Bando, Izuki; Mennear, John H; Bernard, Bruce K.

Affiliation

Nakamura Y; Product Development Laboratory, Calpis Co., Ltd. 11-10, 5-chome, Fuchinobe, Sagamihara, Kanagawa 229-0006, Japan. yasunori.nakamura@calpis.co.jp

Int J Toxicol ; 24 Suppl 4: 25-39, 2005.

Article in En | MEDLINE | ID: mdl-16419577

Subject(s)

Oligopeptides/administration & dosage; Administration, Oral; Animals; Bilirubin/blood; Blood Glucose/metabolism; Body Weight/drug effects; Calcium/blood; Chemistry, Clinical; Corneal Opacity/diagnosis; Dogs; Dose-Response Relationship, Drug; Eating/drug effects; Female; Hematology/methods; Hemoglobins/analysis; Hemoglobins/drug effects; Male; Monocytes/drug effects; Oligopeptides/chemical synthesis; Oligopeptides/chemistry; Oligopeptides/toxicity; Organ Size/drug effects; Ornithine Carbamoyltransferase/blood; Rats; Sex Factors; Species Specificity; Specific Gravity/drug effects; Time Factors; Toxicity Tests/methods; Urinalysis; gamma-Glutamyltransferase/blood

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Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Int J Toxicol Journal subject: TOXICOLOGIA Year: 2005 Document type: Article Affiliation country: Japan Country of publication: United States

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