Cholesterol and its anionic derivatives inhibit 5-lipoxygenase activation in polymorphonuclear leukocytes and MonoMac6 cells.

Aleksandrov, Dmitry A; Zagryagskaya, Anna N; Pushkareva, Marina A; Bachschmid, Markus; Peters-Golden, Marc; Werz, Oliver; Steinhilber, Dieter; Sud'ina, Galina F

Aleksandrov, Dmitry A; Zagryagskaya, Anna N; Pushkareva, Marina A; Bachschmid, Markus; Peters-Golden, Marc; Werz, Oliver; Steinhilber, Dieter; Sud'ina, Galina F.

Affiliation

Aleksandrov DA; A.N. Belozersky Institute of Physicochemical Biology, Moscow State University, Russia.

FEBS J ; 273(3): 548-57, 2006 Feb.

Article in En | MEDLINE | ID: mdl-16420478

Subject(s)

Arachidonate 5-Lipoxygenase/metabolism; Cholesterol/analogs & derivatives; Cholesterol/pharmacology; Lipoxygenase Inhibitors; Neutrophils/metabolism; Anions/pharmacology; Arachidonate 5-Lipoxygenase/isolation & purification; Arachidonic Acid/antagonists & inhibitors; Calcimycin/pharmacology; Cell Line; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Chlorpromazine/pharmacology; Cholesterol Esters/antagonists & inhibitors; Cholesterol Esters/pharmacology; Cytochalasin D/pharmacology; Enzyme Activation/drug effects; Humans; Leukotrienes/biosynthesis; Monocytes/drug effects; Monocytes/enzymology; Monocytes/metabolism; Neutrophils/drug effects; Neutrophils/enzymology

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Collection: 01-internacional Database: MEDLINE Main subject: Arachidonate 5-Lipoxygenase / Cholesterol / Lipoxygenase Inhibitors / Neutrophils Limits: Humans Language: En Journal: FEBS J Journal subject: BIOQUIMICA Year: 2006 Document type: Article Affiliation country: RUSSIA Country of publication: United kingdom

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