The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.

Walton, M I; Wolf, C R; Workman, P

Walton, M I; Wolf, C R; Workman, P.

Affiliation

Walton MI; MRC Clinical Oncology Unit, MRC Centre, Cambridge, U.K.

Biochem Pharmacol ; 44(2): 251-9, 1992 Jul 22.

Article in En | MEDLINE | ID: mdl-1642640

Subject(s)

Cytochrome P-450 Enzyme System/metabolism; Microsomes, Liver/enzymology; NADPH-Ferrihemoprotein Reductase/metabolism; Triazines/metabolism; Animals; Biotransformation; Carbon Monoxide/pharmacology; Cell Hypoxia; Cell Survival; Male; Mice; Mice, Inbred C3H; Microsomes, Liver/drug effects; NADPH-Ferrihemoprotein Reductase/antagonists & inhibitors; NADPH-Ferrihemoprotein Reductase/immunology; Phenobarbital; Tirapazamine

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Collection: 01-internacional Database: MEDLINE Main subject: Triazines / Microsomes, Liver / NADPH-Ferrihemoprotein Reductase / Cytochrome P-450 Enzyme System Limits: Animals Language: En Journal: Biochem Pharmacol Year: 1992 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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