Asymmetric usage of antagonist charged residues drives interleukin-5 receptor recruitment but is insufficient for receptor activation.

Ishino, Tetsuya; Pillalamarri, Udaya; Panarello, Dominick; Bhattacharya, Madhushree; Urbina, Cecilia; Horvat, Stephanie; Sarkhel, Sanjay; Jameson, Bradford; Chaiken, Irwin

Ishino, Tetsuya; Pillalamarri, Udaya; Panarello, Dominick; Bhattacharya, Madhushree; Urbina, Cecilia; Horvat, Stephanie; Sarkhel, Sanjay; Jameson, Bradford; Chaiken, Irwin.

Affiliation

Ishino T; Department of Biochemistry and Molecular Biology and A. J. Drexel Institute of Basic and Applied Protein Science, Drexel University College of Medicine Pennsylvania 19102, USA.

Biochemistry ; 45(4): 1106-15, 2006 Jan 31.

Article in En | MEDLINE | ID: mdl-16430207

Subject(s)

Peptides, Cyclic/metabolism; Receptors, Interleukin/metabolism; Amino Acid Sequence; Animals; Arginine/chemistry; Arginine/metabolism; Drosophila/metabolism; Epitopes/chemistry; Epitopes/metabolism; Histidine/chemistry; Histidine/metabolism; Humans; Interleukin-5 Receptor alpha Subunit; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Peptides, Cyclic/chemistry; Peptides, Cyclic/pharmacology; Protein Binding; Protein Structure, Tertiary; Receptors, Interleukin/antagonists & inhibitors; Receptors, Interleukin/chemistry; Receptors, Interleukin-5; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Structure-Activity Relationship; Surface Plasmon Resonance; Temperature; Thioredoxins/genetics; Thioredoxins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Receptors, Interleukin Limits: Animals / Humans Language: En Journal: Biochemistry Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States

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