Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKbeta.

Nagashima, Kumiko; Sasseville, Vito G; Wen, Danyi; Bielecki, Andrew; Yang, Hua; Simpson, Chris; Grant, Ethan; Hepperle, Michael; Harriman, Gerry; Jaffee, Bruce; Ocain, Tim; Xu, Yajun; Fraser, Christopher C

Nagashima, Kumiko; Sasseville, Vito G; Wen, Danyi; Bielecki, Andrew; Yang, Hua; Simpson, Chris; Grant, Ethan; Hepperle, Michael; Harriman, Gerry; Jaffee, Bruce; Ocain, Tim; Xu, Yajun; Fraser, Christopher C.

Affiliation

Nagashima K; Millennium Pharmaceuticals Inc, 35 Landsdowne St, Cambridge, MA 02139, USA.

Blood ; 107(11): 4266-73, 2006 Jun 01.

Article in En | MEDLINE | ID: mdl-16439676

Subject(s)

I-kappa B Kinase/antagonists & inhibitors; Lymphocyte Depletion/methods; Receptors, Tumor Necrosis Factor, Type I/physiology; Animals; Apoptosis/drug effects; B-Lymphocytes/drug effects; Bone Marrow Cells/drug effects; Enzyme Inhibitors/pharmacology; Granulocytes/drug effects; Granulocytes/metabolism; Hematopoietic Stem Cells/drug effects; Mice; Mice, Knockout; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I/deficiency; Receptors, Tumor Necrosis Factor, Type II/deficiency; Receptors, Tumor Necrosis Factor, Type II/physiology; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Depletion / Receptors, Tumor Necrosis Factor, Type I / I-kappa B Kinase Type of study: Prognostic_studies Limits: Animals Language: En Journal: Blood Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States

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