Atomoxetine enhances a short-term model of plasticity in humans.
Arch Phys Med Rehabil
; 87(2): 216-21, 2006 Feb.
Article
in En
| MEDLINE
| ID: mdl-16442975
ABSTRACT
OBJECTIVE:
To evaluate the role of 2 noradrenergic drugs in modulating use-dependent plasticity in humans.DESIGN:
Double-blind, randomized, and placebo-controlled crossover design.SETTING:
A laboratory in a hospital.PARTICIPANTS:
A convenience sample of 10 healthy subjects. INTERVENTION An established paradigm that measures motor memory as a short-term model of use-dependent plasticity. Subjects attended 3 sessions, separated by at least 1 week to allow drug washout. Subjects received atomoxetine (Strattera), venlafaxine (Effexor), or placebo. MAIN OUTCOMEMEASURE:
Increase in the proportion of movements into the training target zone (TTZ), an indicator of enhanced plasticity.RESULTS:
Atomoxetine, but not venlafaxine, significantly increased movements into the TTZ.CONCLUSIONS:
These results support a role for norepinephrine in enhancing cortical plasticity and suggest potential benefits in using these drugs for improving motor recovery after stroke.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Propylamines
/
Adrenergic Uptake Inhibitors
/
Cyclohexanols
/
Neuronal Plasticity
Type of study:
Clinical_trials
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Arch Phys Med Rehabil
Year:
2006
Document type:
Article
Affiliation country:
United States