Factor VIIa inhibitors: a prodrug strategy to improve oral bioavailability.

Riggs, Jennifer R; Kolesnikov, Aleksandr; Hendrix, John; Young, Wendy B; Shrader, William D; Vijaykumar, Dange; Stephens, Robin; Liu, Liang; Pan, Lin; Mordenti, Joyce; Green, Michael J; Sukbuntherng, Juthamas

Riggs, Jennifer R; Kolesnikov, Aleksandr; Hendrix, John; Young, Wendy B; Shrader, William D; Vijaykumar, Dange; Stephens, Robin; Liu, Liang; Pan, Lin; Mordenti, Joyce; Green, Michael J; Sukbuntherng, Juthamas.

Affiliation

Riggs JR; Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA. jennifer.riggs@yahoo.com

Bioorg Med Chem Lett ; 16(8): 2224-8, 2006 Apr 15.

Article in En | MEDLINE | ID: mdl-16458507

Subject(s)

Amidines/chemistry; Carbamates/chemistry; Factor VIIa/antagonists & inhibitors; Prodrugs/pharmacokinetics; Administration, Oral; Amidines/pharmacology; Animals; Biological Availability; Carbamates/pharmacology; Male; Prodrugs/chemical synthesis; Prodrugs/pharmacology; Rats; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Carbamates / Prodrugs / Factor VIIa / Amidines Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Document type: Article Affiliation country: United States

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