Genotoxicity of the marine toxin okadaic acid, in human Caco-2 cells and in mice gut cells.

Le Hégarat, Ludovic; Jacquin, Anne-Gaëlle; Bazin, Emmanuelle; Fessard, Valérie

Le Hégarat, Ludovic; Jacquin, Anne-Gaëlle; Bazin, Emmanuelle; Fessard, Valérie.

Affiliation

Le Hégarat L; AFSSA, Unité de Toxicologie Génétique des Contaminants Alimentaires, La Haute Marche, BP 90203, 35133 Fougères, France.

Environ Toxicol ; 21(1): 55-64, 2006 Feb.

Article in En | MEDLINE | ID: mdl-16463260

Subject(s)

Aneugens/toxicity; Marine Toxins/toxicity; Okadaic Acid/toxicity; Animals; Apoptosis/drug effects; Caco-2 Cells; Colon/drug effects; Colon/metabolism; Duodenum/drug effects; Duodenum/metabolism; Female; Food Contamination; Humans; Ileum/drug effects; Ileum/metabolism; In Situ Nick-End Labeling; Kidney/drug effects; Liver/drug effects; Liver/metabolism; Marine Toxins/pharmacokinetics; Mice; Micronuclei, Chromosome-Defective/chemically induced; Micronucleus Tests; Mitosis/drug effects; Okadaic Acid/pharmacokinetics

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Collection: 01-internacional Database: MEDLINE Main subject: Okadaic Acid / Aneugens / Marine Toxins Limits: Animals / Female / Humans Language: En Journal: Environ Toxicol Journal subject: SAUDE AMBIENTAL / TOXICOLOGIA Year: 2006 Document type: Article Affiliation country: France Country of publication: United States

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