Tumoricidal effect of calicheamicin immuno-conjugates using a passive targeting strategy.

Boghaert, Erwin R; Khandke, Kiran; Sridharan, Latha; Armellino, Douglas; Dougher, Maureen; Dijoseph, John F; Kunz, Arthur; Hamann, Philip R; Sridharan, Ashwin; Jones, Stanley; Discafani, Carolyn; Damle, Nitin K

Boghaert, Erwin R; Khandke, Kiran; Sridharan, Latha; Armellino, Douglas; Dougher, Maureen; Dijoseph, John F; Kunz, Arthur; Hamann, Philip R; Sridharan, Ashwin; Jones, Stanley; Discafani, Carolyn; Damle, Nitin K.

Affiliation

Boghaert ER; Wyeth Research, Pearl River, NY 10965, USA. boghaee@wyeth.com

Int J Oncol ; 28(3): 675-84, 2006 Mar.

Article in En | MEDLINE | ID: mdl-16465373

Subject(s)

Aminoglycosides/therapeutic use; Antibodies, Monoclonal/therapeutic use; Antineoplastic Agents/therapeutic use; Immunoconjugates/therapeutic use; Xenograft Model Antitumor Assays/methods; Aminoglycosides/pharmacokinetics; Aminoglycosides/pharmacology; Animals; Antibodies, Monoclonal/pharmacokinetics; Antibodies, Monoclonal/pharmacology; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents/pharmacokinetics; Antineoplastic Agents/pharmacology; Cell Line, Tumor; Cell Survival/drug effects; Female; Gemtuzumab; HT29 Cells; Humans; Immunoconjugates/pharmacokinetics; Immunoconjugates/pharmacology; Immunoglobulin Fc Fragments/chemistry; Immunoglobulin Fc Fragments/therapeutic use; Inhibitory Concentration 50; Male; Mice; Mice, Nude; Polyethylene Glycols/chemistry; Rituximab; Serum Albumin/therapeutic use

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Collection: 01-internacional Database: MEDLINE Main subject: Immunoconjugates / Xenograft Model Antitumor Assays / Aminoglycosides / Antibodies, Monoclonal / Antineoplastic Agents Limits: Animals / Female / Humans / Male Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2006 Document type: Article Affiliation country: United States Country of publication: Greece

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