A MUC1/IL-18 DNA vaccine induces anti-tumor immunity and increased survival in MUC1 transgenic mice.

Snyder, Linda A; Goletz, Theresa J; Gunn, George R; Shi, Frank F; Harris, Michael C; Cochlin, Karyn; McCauley, Christine; McCarthy, Stephen G; Branigan, Patrick J; Knight, David M

Snyder, Linda A; Goletz, Theresa J; Gunn, George R; Shi, Frank F; Harris, Michael C; Cochlin, Karyn; McCauley, Christine; McCarthy, Stephen G; Branigan, Patrick J; Knight, David M.

Affiliation

Snyder LA; Centocor Inc., 145 King of Prussia Road, Radnor, PA 19087, USA. LSnyder2@CNTUS.JNJ.COM

Vaccine ; 24(16): 3340-52, 2006 Apr 12.

Article in En | MEDLINE | ID: mdl-16472547

Subject(s)

Antigens, Neoplasm/immunology; Cancer Vaccines/immunology; Interleukin-18/immunology; Mucins/immunology; Neoplasms, Experimental/prevention & control; Vaccines, DNA/immunology; Adjuvants, Immunologic; Amino Acid Sequence; Animals; Antigens, Neoplasm/genetics; Base Sequence; CD4-Positive T-Lymphocytes/immunology; Cancer Vaccines/administration & dosage; Cancer Vaccines/genetics; Cell Line, Tumor; Female; Genetic Vectors; Interleukin-18/genetics; Lymphocyte Depletion; Lymphocyte Subsets/immunology; Mice; Mice, Transgenic; Molecular Sequence Data; Mucin-1; Mucins/genetics; Neoplasms, Experimental/immunology; Plasmids; Survival Analysis; Vaccines, DNA/administration & dosage; Vaccines, DNA/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Cancer Vaccines / Vaccines, DNA / Interleukin-18 / Mucins / Antigens, Neoplasm / Neoplasms, Experimental Limits: Animals Language: En Journal: Vaccine Year: 2006 Document type: Article Affiliation country: United States

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