Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites.

Zamek-Gliszczynski, Maciej J; Hoffmaster, Keith A; Nezasa, Ken-ichi; Tallman, Melanie N; Brouwer, Kim L R

Zamek-Gliszczynski, Maciej J; Hoffmaster, Keith A; Nezasa, Ken-ichi; Tallman, Melanie N; Brouwer, Kim L R.

Affiliation

Zamek-Gliszczynski MJ; University of North Carolina at Chapel Hill, School of Pharmacy, Chapel Hill, NC 27599, USA.

Eur J Pharm Sci ; 27(5): 447-86, 2006 Apr.

Article in En | MEDLINE | ID: mdl-16472997

Subject(s)

Glucuronides/metabolism; Glutathione/metabolism; Liver/metabolism; Membrane Transport Proteins/metabolism; Metabolic Detoxication, Phase II; Pharmaceutical Preparations/metabolism; Sulfates/metabolism; Animals; Bile/metabolism; Cholestasis/metabolism; Drug Evaluation, Preclinical; Glucuronides/chemistry; Glutathione/chemistry; Humans; Liver/enzymology; Multidrug Resistance-Associated Proteins/metabolism; Species Specificity; Sulfates/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Sulfates / Pharmaceutical Preparations / Glucuronides / Metabolic Detoxication, Phase II / Glutathione / Liver Limits: Animals / Humans Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2006 Document type: Article Affiliation country: United States

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