Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors.

Teague, Ryan M; Sather, Blythe D; Sacks, Jilian A; Huang, Maria Z; Dossett, Michelle L; Morimoto, Junko; Tan, Xiaoxio; Sutton, Susan E; Cooke, Michael P; Ohlén, Claes; Greenberg, Philip D

Teague, Ryan M; Sather, Blythe D; Sacks, Jilian A; Huang, Maria Z; Dossett, Michelle L; Morimoto, Junko; Tan, Xiaoxio; Sutton, Susan E; Cooke, Michael P; Ohlén, Claes; Greenberg, Philip D.

Affiliation

Teague RM; Department of Immunology, University of Washington School of Medicine, Office H-564 HSC, Box 357650, Seattle, Washington 98195, USA.

Nat Med ; 12(3): 335-41, 2006 Mar.

Article in En | MEDLINE | ID: mdl-16474399

Subject(s)

CD8-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/immunology; Immune Tolerance/immunology; Immunotherapy, Adoptive; Interleukin-15/pharmacology; Neoplasms/therapy; Animals; CD8 Antigens/metabolism; CD8-Positive T-Lymphocytes/cytology; Cell Proliferation; Fas Ligand Protein; Humans; Immunologic Memory/immunology; Membrane Glycoproteins/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, Interleukin-15; Receptors, Interleukin-2/metabolism; Tumor Necrosis Factors/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Immunotherapy, Adoptive / CD8-Positive T-Lymphocytes / Interleukin-15 / Immune Tolerance / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2006 Document type: Article Affiliation country: United States

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