Biophysical assessment of atopic dermatitis skin and effects of a moisturizer.
Clin Exp Dermatol
; 31(2): 272-7, 2006 Mar.
Article
in En
| MEDLINE
| ID: mdl-16487108
ABSTRACT
BACKGROUND:
The mechanisms of the skin barrier impairment in patients with atopic dermatitis (AD) are still unknown and need further studying.OBJECTIVE:
We evaluated the skin of healthy subjects and of patients having atopic dermatitis with an instrument measuring electrical impedance and other noninvasive methods (transepidermal water loss, capacitance) and studied the effects of a new emollient [Proderm (Pro-Q in the USA)].METHODS:
After a 2-week washout period, we treated clinically noneczematous skin on the forearm of 24 patients with AD and assessed the effects with the noninvasive methods. 22 healthy subjects were used as controls.RESULTS:
The findings indicate that barrier function and hydration, and certain patterns of electrical impedance of AD skin are abnormal compared with normal skin. Moreover, there was an increase in hydration in patients' skin after treatment and a reversal of certain impedance indices towards normal.CONCLUSIONS:
Our findings demonstrate that the moisturizer we used changes some biophysical parameters when applied to atopic skin. In addition, a technique based on electrical impedance seems to give valuable information in atopic skin studies, especially the effects of moisturizers.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dermatitis, Atopic
/
Emollients
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Adult
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Exp Dermatol
Year:
2006
Document type:
Article
Affiliation country:
Sweden