Concerted synthesis of a spirobicyclic type-VI beta-turn mimic of Pro-Pro-Pro-NH2.
Org Lett
; 8(5): 983-6, 2006 Mar 02.
Article
in En
| MEDLINE
| ID: mdl-16494490
A highly concerted strategy for the synthesis of symmetrical type-VI beta-turn mimics was formulated. A proof of concept is presented in the synthesis of a spirobicyclic peptidomimetic of Pro-Pro-Pro-NH2, compound 6. The formation of an unusual adduct that was encountered in the process also is reported. This approach is potentially general for type-VI beta-turn mimics where the i+1 and i+2 residues are identical.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oligopeptides
/
Spiro Compounds
/
Models, Molecular
/
Bridged Bicyclo Compounds, Heterocyclic
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2006
Document type:
Article
Affiliation country:
United States
Country of publication:
United States