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Spinal epidural extraskeletal Ewing sarcoma in an adolescent boy: a case report.
Athanassiadou, Fani; Tragiannidis, Athanassios; Kourti, Maria; Papageorgiou, Theodotis; Kotoula, Vassiliki; Kontopoulos, Vassilios; Christoforidis, John.
Affiliation
  • Athanassiadou F; 2nd Pediatric Department, Hematology-Oncology Unit, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. atragian@hotmail.com
Pediatr Hematol Oncol ; 23(3): 263-7, 2006.
Article in En | MEDLINE | ID: mdl-16517542
Extraskeletal Ewing sarcoma (EES) represents a rare soft tissue malignant neoplasm histologically similar to skeletal Ewing sarcoma. It occurs mainly in adolescents and young adults and commonly affects the paravertebral regions. The differential diagnosis includes other small, blue round cells tumors. The authors report a case of an EES involving the spinal epidural and paravertebral spaces in an adolescent boy. EES diagnosis was confirmed by features of histologic analysis and immunohistochemistry and by the presence of the t(11;22)(q24;q12) chromosomal translocation by reverse transcriptase-polymerase chain reaction.
Subject(s)
Sarcoma, Ewing/diagnosis; Soft Tissue Neoplasms/diagnosis; Adolescent; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Back Pain/etiology; Biomarkers, Tumor/analysis; Chromosomes, Human, Pair 11/genetics; Chromosomes, Human, Pair 11/ultrastructure; Chromosomes, Human, Pair 22/genetics; Chromosomes, Human, Pair 22/ultrastructure; Combined Modality Therapy; Cyclophosphamide/administration & dosage; DNA, Neoplasm/genetics; Doxorubicin/administration & dosage; Epidural Space; Etoposide/administration & dosage; Fractures, Compression/etiology; Fractures, Spontaneous/etiology; Humans; Ifosfamide/administration & dosage; Laminectomy; Magnetic Resonance Imaging; Male; Mesna/administration & dosage; Neoplasm Proteins/analysis; Oncogene Proteins, Fusion/analysis; Oncogene Proteins, Fusion/genetics; Proto-Oncogene Protein c-fli-1; RNA-Binding Protein EWS; Radiotherapy, Adjuvant; Reverse Transcriptase Polymerase Chain Reaction; Sarcoma, Ewing/chemistry; Sarcoma, Ewing/diagnostic imaging; Sarcoma, Ewing/drug therapy; Sarcoma, Ewing/genetics; Sarcoma, Ewing/pathology; Sarcoma, Ewing/surgery; Soft Tissue Neoplasms/chemistry; Soft Tissue Neoplasms/diagnostic imaging; Soft Tissue Neoplasms/drug therapy; Soft Tissue Neoplasms/genetics; Soft Tissue Neoplasms/pathology; Soft Tissue Neoplasms/surgery; Spinal Fractures/etiology; Thoracic Vertebrae/surgery; Tomography, X-Ray Computed; Transcription Factors/analysis; Transcription Factors/genetics; Translocation, Genetic; Vincristine/administration & dosage
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Collection: 01-internacional Database: MEDLINE Main subject: Sarcoma, Ewing / Soft Tissue Neoplasms Type of study: Etiology_studies Language: En Journal: Pediatr Hematol Oncol Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2006 Document type: Article Affiliation country: Greece Country of publication: United kingdom
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Collection: 01-internacional Database: MEDLINE Main subject: Sarcoma, Ewing / Soft Tissue Neoplasms Type of study: Etiology_studies Language: En Journal: Pediatr Hematol Oncol Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2006 Document type: Article Affiliation country: Greece Country of publication: United kingdom