Donor methylenetetrahydrofolate reductase genotype is associated with graft-versus-host disease in hematopoietic stem cell transplant patients treated with methotrexate.

Murphy, N; Diviney, M; Szer, J; Bardy, P; Grigg, A; Hoyt, R; King, B; Macgregor, L; Holdsworth, R; McCluskey, J; Tait, B D

Murphy, N; Diviney, M; Szer, J; Bardy, P; Grigg, A; Hoyt, R; King, B; Macgregor, L; Holdsworth, R; McCluskey, J; Tait, B D.

Affiliation

Murphy N; Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, Melbourne, Australia.

Bone Marrow Transplant ; 37(8): 773-9, 2006 Apr.

Article in En | MEDLINE | ID: mdl-16518429

Subject(s)

Genotype; Hematopoietic Stem Cell Transplantation/methods; Methotrexate/therapeutic use; Methylenetetrahydrofolate Reductase (NADPH2)/genetics; Tissue Donors; Adolescent; Adult; Aged; Cohort Studies; DNA/chemistry; Female; Folic Acid/metabolism; Graft vs Host Disease; Humans; Male; Middle Aged; Models, Statistical; Multivariate Analysis; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Proportional Hazards Models; Stem Cell Transplantation; Stem Cells/cytology; Time Factors; Transplantation Conditioning; Transplantation, Homologous; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Tissue Donors / Methotrexate / Hematopoietic Stem Cell Transplantation / Methylenetetrahydrofolate Reductase (NADPH2) / Genotype Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Bone Marrow Transplant Journal subject: TRANSPLANTE Year: 2006 Document type: Article Affiliation country: Australia Country of publication: United kingdom

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