SAR studies: designing potent and selective LXR agonists.

Szewczyk, Jason W; Huang, Shaei; Chin, Jayne; Tian, Jenny; Mitnaul, Lyndon; Rosa, Raymond L; Peterson, Larry; Sparrow, Carl P; Adams, Alan D

Szewczyk, Jason W; Huang, Shaei; Chin, Jayne; Tian, Jenny; Mitnaul, Lyndon; Rosa, Raymond L; Peterson, Larry; Sparrow, Carl P; Adams, Alan D.

Affiliation

Szewczyk JW; Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA. jason_szewczyk@merck.com

Bioorg Med Chem Lett ; 16(11): 3055-60, 2006 Jun 01.

Article in En | MEDLINE | ID: mdl-16529931

Subject(s)

DNA-Binding Proteins/agonists; Drug Design; Receptors, Cytoplasmic and Nuclear/agonists; Acids/chemistry; Amination; Aniline Compounds/chemistry; Animals; Cholesterol, HDL/blood; Cyclization; Indoles/chemistry; Liver X Receptors; Mice; Molecular Structure; Orphan Nuclear Receptors; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Receptors, Cytoplasmic and Nuclear / DNA-Binding Proteins Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Document type: Article Affiliation country: United States Country of publication: United kingdom

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