Comparison of stable nitroxide, 3-substituted 2,2,5,5-tetramethylpyrrolidine-N-oxyls, with respect to protection from radiation, prevention of DNA damage, and distribution in mice.

Anzai, Kazunori; Ueno, Megumi; Yoshida, Akira; Furuse, Masako; Aung, Winn; Nakanishi, Ikuo; Moritake, Takashi; Takeshita, Keizo; Ikota, Nobuo

Anzai, Kazunori; Ueno, Megumi; Yoshida, Akira; Furuse, Masako; Aung, Winn; Nakanishi, Ikuo; Moritake, Takashi; Takeshita, Keizo; Ikota, Nobuo.

Affiliation

Anzai K; Redox Regulation Research Group, National Institute of Radiological Sciences, 4-9-1 Anagawa, Chiba 263-8555, Japan. anzai@nirs.go.jp

Free Radic Biol Med ; 40(7): 1170-8, 2006 Apr 01.

Article in En | MEDLINE | ID: mdl-16545684

Subject(s)

Cyclic N-Oxides/pharmacology; DNA Damage/drug effects; Peroxides/pharmacology; Pyrrolidines/pharmacology; Radiation-Protective Agents/pharmacology; 8-Hydroxy-2'-Deoxyguanosine; Animals; Body Temperature/drug effects; Bone Marrow/metabolism; Cell Line, Tumor; Cyclic N-Oxides/chemistry; Cyclic N-Oxides/pharmacokinetics; DNA/radiation effects; Deoxyguanosine/analogs & derivatives; Deoxyguanosine/biosynthesis; Heart Rate/drug effects; Leukemia L5178; Male; Mice; Oxidation-Reduction; Pyrrolidines/chemistry; Pyrrolidines/pharmacokinetics; Salmon; Whole-Body Irradiation

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Collection: 01-internacional Database: MEDLINE Main subject: Peroxides / Pyrrolidines / Radiation-Protective Agents / DNA Damage / Cyclic N-Oxides Limits: Animals Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2006 Document type: Article Affiliation country: Japan Country of publication: United States

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