Studies on apple and blueberry fruit constituents: do the polyphenols reach the colon after ingestion?
Mol Nutr Food Res
; 50(4-5): 418-23, 2006 Apr.
Article
in En
| MEDLINE
| ID: mdl-16548015
ABSTRACT
The aim of our studies was to determine the amount of polyphenols reaching the colon after oral intake of apple juice and blueberries. After a polyphenol-free diet healthy ileostomy volunteers consumed a polyphenol-rich cloudy apple juice while others consumed anthocyanin-rich blueberries. Ileostomy effluent was collected and polyphenols were identified using HPLC-DAD as well as HPLC-ESI-MS/MS; quantification was performed with HPLC-DAD. Most of the orally administered apple polyphenols were absorbed from or metabolized in the small intestine. Between 0 and 33% of the oral dose was recovered in the ileostomy bags with a maximum of excretion after 2 h. A higher amount of the blueberry anthocyanins under study (up to 85%, depending on the sugar moiety) were determined in the ileostomy bags and therefore would reach the colon under physiological circumstances. Such structure-related availability has to be considered when polyphenols are used in model systems to study potential preventive effects in colorectal diseases.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenols
/
Flavonoids
/
Colon
/
Blueberry Plants
/
Malus
/
Fruit
Limits:
Humans
Language:
En
Journal:
Mol Nutr Food Res
Journal subject:
CIENCIAS DA NUTRICAO
Year:
2006
Document type:
Article
Affiliation country:
Germany