Beta-interferon topical treatment in low and high risk cervical lesions.
Clin Exp Obstet Gynecol
; 18(2): 91-7, 1991.
Article
in En
| MEDLINE
| ID: mdl-1655314
ABSTRACT
In a series of 131 patients we evaluated the effects of medical therapy with beta-Interferon cream in patients with cervical Human Papilloma Virus (HPV) infection, which in some cases, was associated with CIN. Treatment consisted of the direct daily application of 1,000,000 IU beta-Interferon cream to colposcopically positive areas over a period of 15 days. At intervals of 1, 6, 12 and 24 months following treatment, cytohistological tests were carried out to assess the effects of treatment. At the 24-month control, the overall percentage for regression was 79.57% of cases. Regression was observed in 58.33% of patients with cytohistological changes associated with HPV without atypia, and in 69.85% of patients with HPV with atypia (38.9% total regression). The regression pattern for CIN lesions was as follows in CIN lesions, regression occurred in 85.36%, in CIN II in 84.20%, and 37.5% of CIN III cases showed total regression.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Papillomaviridae
/
Tumor Virus Infections
/
Uterine Cervical Diseases
/
Interferon-beta
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Clin Exp Obstet Gynecol
Year:
1991
Document type:
Article
Affiliation country:
Italy