Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene.
Neurology
; 66(12): 1917-9, 2006 Jun 27.
Article
in En
| MEDLINE
| ID: mdl-16554494
The G1246A polymorphism in the gene of the hypocretin receptor 2 (HCRTR2) has been linked to the risk for cluster headache (CH). The authors examined this association in a large sample of 226 patients with CH and 266 controls from Germany. The genotype and allele distribution varied significantly between patients and controls. Homozygous carriers of the G-allele had a twofold increase in risk for CH (OR 1.97; 95% CI 1.32 to 2.92; p = 0.0007).
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Testing
/
Cluster Headache
/
Receptors, Neuropeptide
/
Risk Assessment
Type of study:
Clinical_trials
/
Etiology_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Neurology
Year:
2006
Document type:
Article
Affiliation country:
Germany
Country of publication:
United States