Anti-histone antibodies in subacute sensory neuropathy.
J Neurooncol
; 11(1): 71-5, 1991 Aug.
Article
in En
| MEDLINE
| ID: mdl-1655989
ABSTRACT
We investigated the levels of anti-histone antibodies in the sera of 7 patients with subacute sensory neuropathy. IgG antibodies to histones H1 and H3 were significantly elevated in 4 of these patients. The anti-H1 antibodies reacted mainly with determinants located in the central globular and the carboxy-terminal domain of the H1 molecule. We also observed reactivity of these sera with histone H1 zero, a variant found in terminally-differentiated cells such as neurons. This study suggests a potential for histones to serve as autoantigens in humorally-mediated paraneoplastic diseases.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paraneoplastic Syndromes
/
Autoantibodies
/
Immunoglobulin G
/
Immunoglobulin M
/
Histones
/
Peripheral Nervous System Diseases
Limits:
Humans
Language:
En
Journal:
J Neurooncol
Year:
1991
Document type:
Article