Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds.
Chin J Integr Med
; 12(1): 46-9, 2006 Mar.
Article
in En
| MEDLINE
| ID: mdl-16571284
ABSTRACT
OBJECTIVE:
To study the effect of Yangqixue Qufengshi Recipe (YQXQFS) on rheumatoid arthritis (RA) model mice under different genetic backgrounds.METHODS:
Collagen Induced Arthritis (CIA) were established on HLA-DR4 transgenic (TG) mice and non-transgenic (NTG) mice, which partly were raised with YQXQFS, and the onset day of CIA, the level of type II collagen (CII)-reactive antibodies and the pathological scores of CIA were assessed.RESULTS:
Under HLA-DR4 TG background (compared with NTG mice), the earlier onset day of CIA (11.22 +/- 3.35 days vs 16.56 +/- 4.75 days, P < 0.05) and higher level of CII-reactive antibodies (0.2274 +/- 0.1390 microg/ml vs 0.1101 +/- 0.0560 microg/ml, P < 0.05) were observed, but the pathological scores of CIA remained unchanged. YQXQFS could not influence the onset day of CIA and the level of CII-reactive antibodies, but had a certain effect on the total pathological scores (6.56 +/- 3.43 scores vs 11.11 +/- 5.64 scores) and bone erosion (0.22 +/- 0.44 scores vs 1.67 +/- 1.50 scores) of CIA on NTG mice (P < 0.05), NTG YQXQFS group compared with NTG experimental group.CONCLUSION:
YQXQFS had a certain effect on RA model, but had no significant effect on HLA-DR4 related CIA.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis, Experimental
/
Arthritis, Rheumatoid
/
Drugs, Chinese Herbal
/
Antirheumatic Agents
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Chin J Integr Med
Journal subject:
TERAPIAS COMPLEMENTARES
Year:
2006
Document type:
Article