Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.

Mulligan, Jude M; Greene, Lisa M; Cloonan, Suzanne; Mc Gee, Margaret M; Onnis, Valeria; Campiani, Giuseppe; Fattorusso, Caterina; Lawler, Mark; Williams, D Clive; Zisterer, Daniela M

Mulligan, Jude M; Greene, Lisa M; Cloonan, Suzanne; Mc Gee, Margaret M; Onnis, Valeria; Campiani, Giuseppe; Fattorusso, Caterina; Lawler, Mark; Williams, D Clive; Zisterer, Daniela M.

Affiliation

Mulligan JM; School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland.

Mol Pharmacol ; 70(1): 60-70, 2006 Jul.

Article in En | MEDLINE | ID: mdl-16571652

Subject(s)

Apoptosis/drug effects; Oxazepines/pharmacology; Pyrroles/pharmacology; Tubulin/metabolism; Antineoplastic Agents, Phytogenic/metabolism; Antineoplastic Agents, Phytogenic/pharmacology; Binding Sites; Binding, Competitive; Blotting, Western; CDC2 Protein Kinase/metabolism; Carbamates/pharmacology; Cell Division; Cell Line, Tumor; Colchicine/metabolism; Colchicine/pharmacology; Cyclin B/metabolism; Cyclin B1; Dose-Response Relationship, Drug; G2 Phase; Humans; K562 Cells; Metaphase/drug effects; Microtubules/drug effects; Microtubules/metabolism; Oxazepines/metabolism; Pyrroles/metabolism; Time Factors; Vinblastine/metabolism; Vinblastine/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Oxazepines / Pyrroles / Tubulin / Apoptosis Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Mol Pharmacol Year: 2006 Document type: Article Affiliation country: Ireland Country of publication: United States

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