[Marginal zone lymphoma associated with Sjögren's syndrome and hepatitis C virus infection].
Nihon Rinsho Meneki Gakkai Kaishi
; 24(4): 160-7, 2001 Aug.
Article
in Ja
| MEDLINE
| ID: mdl-16578967
ABSTRACT
A 64-year-old female was admitted in May 1997, because of salivary gland swelling. Histology of the right parotid gland revealed malignant lymphoma, diffuse medium-sized B-cell type, and she was treated with local radiotherapy and chemotherapy. She was rehospitalized in April 1998, because of recurrence of lymphoma in the stomach and the sigmoid colon. She had splenomegaly and lymphadenopathy (neck and inguinal). Laboratory findings revealed marked elevation of rheumatoid factor and RNA of hepatitis C virus. A diagnosis of Sjogren's syndrome was made by dryness and the histological findings of labial biopsy. Marginal zone B-cell lymphoma mainly consisted of centrocyte-like cells and lymphoepithelial lesions, and CD 20 and IgM-kappa were positive with immunohistochemical staining. Lymphoma involved the gut and spleen. We discuss the correlation of malignant lymphoma with Sjogren's syndrome and HCV infection.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parotid Neoplasms
/
Sjogren's Syndrome
/
Lymphoma, B-Cell
/
Hepatitis C
Type of study:
Risk_factors_studies
Limits:
Female
/
Humans
/
Middle aged
Language:
Ja
Journal:
Nihon Rinsho Meneki Gakkai Kaishi
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2001
Document type:
Article