Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice.

Albertelli, Megan A; Scheller, Arno; Brogley, Michele; Robins, Diane M

Albertelli, Megan A; Scheller, Arno; Brogley, Michele; Robins, Diane M.

Affiliation

Albertelli MA; Department of Human Genetics, 4909 Buhl Bldg, University of Michigan Medical School, Ann Arbor, Michigan 48109-0618, USA.

Mol Endocrinol ; 20(6): 1248-60, 2006 Jun.

Article in En | MEDLINE | ID: mdl-16601069

Subject(s)

Receptors, Androgen/genetics; Receptors, Androgen/physiology; Alleles; Animals; Base Sequence; DNA, Recombinant/genetics; Female; Gene Expression; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental/etiology; Peptides/chemistry; Peptides/genetics; Phenotype; Prostate/anatomy & histology; Prostate/physiology; Prostatic Neoplasms/etiology; Receptors, Androgen/chemistry; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Testis/anatomy & histology; Testis/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Androgen Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Mol Endocrinol Journal subject: BIOLOGIA MOLECULAR / ENDOCRINOLOGIA Year: 2006 Document type: Article Affiliation country: United States

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