A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q.

Kang, Young-Sun; Do, Yoonkyung; Lee, Hae-Kyung; Park, Sung Ho; Cheong, Cheolho; Lynch, Rebecca M; Loeffler, Jutta M; Steinman, Ralph M; Park, Chae Gyu

Kang, Young-Sun; Do, Yoonkyung; Lee, Hae-Kyung; Park, Sung Ho; Cheong, Cheolho; Lynch, Rebecca M; Loeffler, Jutta M; Steinman, Ralph M; Park, Chae Gyu.

Affiliation

Kang YS; Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Cell ; 125(1): 47-58, 2006 Apr 07.

Article in En | MEDLINE | ID: mdl-16615889

Subject(s)

Cell Adhesion Molecules/metabolism; Complement Activation/immunology; Complement C1q/immunology; Complement C1q/metabolism; Lectins, C-Type/metabolism; Polysaccharides, Bacterial/immunology; Receptors, Cell Surface/metabolism; Streptococcus pneumoniae/immunology; Animals; Antigen-Antibody Reactions/immunology; CHO Cells; Complement C3/chemistry; Complement C3/metabolism; Complement Pathway, Classical/immunology; Cricetinae; Cricetulus; Fibroblasts/cytology; Humans; Macrophages/cytology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Protein Binding; Spleen/cytology

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Collection: 01-internacional Database: MEDLINE Main subject: Polysaccharides, Bacterial / Streptococcus pneumoniae / Cell Adhesion Molecules / Complement C1q / Receptors, Cell Surface / Complement Activation / Lectins, C-Type Limits: Animals / Humans Language: En Journal: Cell Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States

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