The role of human nucleoside transporters in cellular uptake of 4'-thio-beta-D-arabinofuranosylcytosine and beta-D-arabinosylcytosine.

Clarke, Marilyn L; Damaraju, Vijaya L; Zhang, Jing; Mowles, Delores; Tackaberry, Tracey; Lang, Thach; Smith, Kyla M; Young, James D; Tomkinson, Blake; Cass, Carol E

Clarke, Marilyn L; Damaraju, Vijaya L; Zhang, Jing; Mowles, Delores; Tackaberry, Tracey; Lang, Thach; Smith, Kyla M; Young, James D; Tomkinson, Blake; Cass, Carol E.

Affiliation

Clarke ML; Department of Oncology, Cross Cancer Institute, 11560 University Ave., Edmonton, AB, T6G 1Z2 Canada.

Mol Pharmacol ; 70(1): 303-10, 2006 Jul.

Article in En | MEDLINE | ID: mdl-16617163

Subject(s)

Arabinonucleosides/pharmacokinetics; Cytarabine/pharmacokinetics; Nucleoside Transport Proteins/physiology; Animals; Arabinonucleosides/metabolism; Arabinonucleosides/pharmacology; Biological Transport/drug effects; Cell Line, Tumor; Cell Survival/drug effects; Cell Survival/genetics; Cytarabine/metabolism; Cytarabine/pharmacology; Cytidine/analogs & derivatives; Cytidine/pharmacology; Dose-Response Relationship, Drug; Equilibrative-Nucleoside Transporter 2/genetics; Equilibrative-Nucleoside Transporter 2/physiology; Female; HeLa Cells; Humans; Membrane Potentials/physiology; Nucleoside Transport Proteins/genetics; Oocytes/metabolism; Oocytes/physiology; Saccharomyces cerevisiae/drug effects; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Thioinosine/analogs & derivatives; Thioinosine/pharmacology; Transfection; Tritium; Uridine/pharmacokinetics; Xenopus laevis

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Collection: 01-internacional Database: MEDLINE Main subject: Arabinonucleosides / Cytarabine / Nucleoside Transport Proteins Limits: Animals / Female / Humans Language: En Journal: Mol Pharmacol Year: 2006 Document type: Article Country of publication: United States

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