Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat.

Freret, Thomas; Valable, Samuel; Chazalviel, Laurent; Saulnier, Romaric; Mackenzie, Eric T; Petit, Edwige; Bernaudin, Myriam; Boulouard, Michel; Schumann-Bard, Pascale

Freret, Thomas; Valable, Samuel; Chazalviel, Laurent; Saulnier, Romaric; Mackenzie, Eric T; Petit, Edwige; Bernaudin, Myriam; Boulouard, Michel; Schumann-Bard, Pascale.

Affiliation

Freret T; CNRS UMR 6185, Cyceron, University of Caen Basse-Normandie, Bvd H. Becquerel F-14074 Caen cedex, France. thomas.freret@unicaen.fr

Eur J Neurosci ; 23(7): 1757-65, 2006 Apr.

Article in En | MEDLINE | ID: mdl-16623832

Subject(s)

Brain/drug effects; Deferoxamine/therapeutic use; Iron Chelating Agents/therapeutic use; Ischemic Attack, Transient/drug therapy; Animals; Behavior, Animal/drug effects; Brain/pathology; Brain/physiopathology; Deferoxamine/administration & dosage; Deferoxamine/pharmacology; Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis; Infarction, Middle Cerebral Artery/complications; Iron Chelating Agents/administration & dosage; Iron Chelating Agents/pharmacology; Ischemic Attack, Transient/etiology; Ischemic Attack, Transient/physiopathology; Male; Motor Activity/drug effects; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Brain / Ischemic Attack, Transient / Iron Chelating Agents / Deferoxamine Type of study: Etiology_studies Limits: Animals Language: En Journal: Eur J Neurosci Journal subject: NEUROLOGIA Year: 2006 Document type: Article Affiliation country: France Country of publication: France

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