Role of the Cys18-Cys274 disulfide bond and of the third extracellular loop in the constitutive activation and internalization of angiotensin II type 1 receptor.

Correa, Silvana A A; Pignatari, Graciela C; Ferro, Emer S; Pacheco, Nelson A S; Costa-Neto, Claudio M; Pesquero, João B; Oliveira, Laerte; Paiva, Antonio C M; Shimuta, Suma I

Correa, Silvana A A; Pignatari, Graciela C; Ferro, Emer S; Pacheco, Nelson A S; Costa-Neto, Claudio M; Pesquero, João B; Oliveira, Laerte; Paiva, Antonio C M; Shimuta, Suma I.

Affiliation

Correa SA; Department of Biophysics, Universidade Federal de São Paulo-Escola Paulista de Medicina, Rua Botucatu 862, 04023-062, São Paulo, SP, Brazil.

Regul Pept ; 134(2-3): 132-40, 2006 May 15.

Article in En | MEDLINE | ID: mdl-16626818

Subject(s)

Cystine/physiology; Disulfides/metabolism; Receptor, Angiotensin, Type 1/physiology; Amino Acid Sequence; Amino Acid Substitution; Angiotensin II/metabolism; Animals; Boron Compounds; CHO Cells; Cricetinae; Cricetulus; Flow Cytometry; Green Fluorescent Proteins/biosynthesis; Inositol Phosphates/biosynthesis; Microscopy, Confocal; Models, Molecular; Protein Structure, Tertiary; Receptor, Angiotensin, Type 1/chemistry; Receptor, Angiotensin, Type 1/genetics; Recombinant Fusion Proteins/biosynthesis; Sequence Alignment

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Collection: 01-internacional Database: MEDLINE Main subject: Cystine / Receptor, Angiotensin, Type 1 / Disulfides Limits: Animals Language: En Journal: Regul Pept Year: 2006 Document type: Article Affiliation country: Brazil Country of publication: Netherlands

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