Complement facilitates macrophage phagocytosis of inhaled iron particles but has little effect in mediating silica-induced lung inflammatory and clearance responses.

Warheit, D B; Carakostas, M C; Bamberger, J R; Hartsky, M A

Warheit, D B; Carakostas, M C; Bamberger, J R; Hartsky, M A.

Affiliation

Warheit DB; Central Research and Development, Haskell Laboratory for Toxicology and Industrial Medicine, E.I. du Pont de Nemours and Company, Newark, Delaware 19714.

Environ Res ; 56(2): 186-203, 1991 Dec.

Article in En | MEDLINE | ID: mdl-1663034

Subject(s)

Complement System Proteins/immunology; Iron/immunology; Lung/immunology; Macrophages/immunology; Silicon Dioxide/toxicity; Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid/chemistry; Bronchoalveolar Lavage Fluid/cytology; Bronchoalveolar Lavage Fluid/enzymology; Cell Count; Cell Survival; Chemotaxis; Iron/administration & dosage; Iron/toxicity; Lung/drug effects; Lung/ultrastructure; Macrophages/ultrastructure; Male; Microscopy, Electron, Scanning; Mucociliary Clearance; Neutrophils; Phagocytosis; Pneumonia/chemically induced; Pneumonia/immunology; Proteins/analysis; Rats; Silicon Dioxide/administration & dosage

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Collection: 01-internacional Database: MEDLINE Main subject: Complement System Proteins / Silicon Dioxide / Iron / Lung / Macrophages Limits: Animals Language: En Journal: Environ Res Year: 1991 Document type: Article

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