Subpopulations of GABA-mediated synaptic potentials in slices of rat dorsal striatum are differentially modulated by presynaptic GABAB receptors.
Brain Res
; 562(2): 332-4, 1991 Oct 25.
Article
in En
| MEDLINE
| ID: mdl-1663417
ABSTRACT
gamma-Aminobutyric acid (GABA)-mediated synaptic potentials in rat dorsal striatum in vitro were reduced in amplitude by the GABAB receptor agonists baclofen and 3-aminopropyl-(methyl)-phosphinic acid (SK&F 97541), without any detectable postsynaptic effect. Synaptic potentials in 40% of neurones were distinctly multiphasic, the components of which exhibited a differential sensitivity to GABAB agonists. One population of GABA-releasing neurones within the striatum had presynaptic GABAB autoreceptors, whereas others were not directly affected by GABAB agonists.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Putamen
/
Synaptic Membranes
/
Caudate Nucleus
/
Receptors, GABA-A
/
Gamma-Aminobutyric Acid
Limits:
Animals
Language:
En
Journal:
Brain Res
Year:
1991
Document type:
Article
Affiliation country:
United kingdom