Cell-based assay for screening 11beta-hydroxysteroid dehydrogenase inhibitors using liquid chromatography/tandem mass spectrometry detection.

Xu, Rongda; Sang, Bi-Ching; Navre, Marc; Kassel, Daniel B

Xu, Rongda; Sang, Bi-Ching; Navre, Marc; Kassel, Daniel B.

Affiliation

Xu R; Takeda San Diego, Inc., 10410 Science Center Dr., San Diego, CA 92121, USA. ron.xu@takedasd.com

Rapid Commun Mass Spectrom ; 20(11): 1643-7, 2006.

Article in En | MEDLINE | ID: mdl-16636996

Subject(s)

11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors; Cortisone/analysis; Enzyme Inhibitors/pharmacology; Hydrocortisone/analysis; 11-beta-Hydroxysteroid Dehydrogenases/genetics; Animals; Calibration; Cells, Cultured; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; HeLa Cells; Humans; Mice; Rats; Tandem Mass Spectrometry

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Collection: 01-internacional Database: MEDLINE Main subject: Cortisone / Hydrocortisone / 11-beta-Hydroxysteroid Dehydrogenases / Enzyme Inhibitors Type of study: Diagnostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: Rapid Commun Mass Spectrom Year: 2006 Document type: Article Affiliation country: United States Country of publication: United kingdom

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