Evaluation of the drug interaction potential of aplaviroc, a novel human immunodeficiency virus entry inhibitor, using a modified cooperstown 5 + 1 cocktail.

Johnson, Brendan M; Song, Ivy H; Adkison, Kimberly K; Borland, Julie; Fang, Lei; Lou, Yu; Berrey, M Michelle; Nafziger, Anne N; Piscitelli, Stephen C; Bertino, Joseph S

Johnson, Brendan M; Song, Ivy H; Adkison, Kimberly K; Borland, Julie; Fang, Lei; Lou, Yu; Berrey, M Michelle; Nafziger, Anne N; Piscitelli, Stephen C; Bertino, Joseph S.

Affiliation

Johnson BM; GlaxoSmithKline, Research Triangle Park, NC 27709, USA. stephen.c.piscitelli@gsk.com

J Clin Pharmacol ; 46(5): 577-87, 2006 May.

Article in En | MEDLINE | ID: mdl-16638741

Subject(s)

Anti-HIV Agents/pharmacokinetics; Benzoates/pharmacokinetics; Piperazines/pharmacokinetics; Spiro Compounds/pharmacokinetics; Adult; Anti-HIV Agents/adverse effects; Anti-HIV Agents/blood; Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases/genetics; Aryl Hydrocarbon Hydroxylases/metabolism; Benzoates/adverse effects; Benzoates/blood; CCR5 Receptor Antagonists; Caffeine/blood; Caffeine/pharmacokinetics; Dextromethorphan/pharmacokinetics; Dextromethorphan/urine; Diketopiperazines; Drug Interactions; Female; Humans; Male; Midazolam/blood; Midazolam/pharmacokinetics; Middle Aged; Omeprazole/blood; Omeprazole/pharmacokinetics; Piperazines/adverse effects; Piperazines/blood; Spiro Compounds/adverse effects; Spiro Compounds/blood; Warfarin/blood; Warfarin/pharmacokinetics

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Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Spiro Compounds / Benzoates / Anti-HIV Agents Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Clin Pharmacol Year: 2006 Document type: Article Affiliation country: United States Country of publication: United kingdom

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