Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival.

Sebastiani, Valeria; Ricci, Francesca; Rubio-Viqueira, Belen; Rubio-Viquiera, Belen; Kulesza, Piotr; Yeo, Charles J; Hidalgo, Manuel; Klein, Alison; Laheru, Daniel; Iacobuzio-Donahue, Christine A

Sebastiani, Valeria; Ricci, Francesca; Rubio-Viqueira, Belen; Rubio-Viquiera, Belen; Kulesza, Piotr; Yeo, Charles J; Hidalgo, Manuel; Klein, Alison; Laheru, Daniel; Iacobuzio-Donahue, Christine A.

Affiliation

Sebastiani V; Department of Pathology, University La Sapienza, Rome, Italy.

Clin Cancer Res ; 12(8): 2492-7, 2006 Apr 15.

Article in En | MEDLINE | ID: mdl-16638857

Subject(s)

Deoxycytidine Kinase/metabolism; Pancreatic Neoplasms/pathology; Antimetabolites, Antineoplastic/pharmacology; Antimetabolites, Antineoplastic/therapeutic use; Cell Line, Tumor; DNA Methylation; DNA Mutational Analysis; DNA, Neoplasm/chemistry; DNA, Neoplasm/genetics; DNA, Neoplasm/metabolism; Deoxycytidine/analogs & derivatives; Deoxycytidine/pharmacology; Deoxycytidine/therapeutic use; Deoxycytidine Kinase/genetics; Drug Resistance/genetics; Female; Humans; Immunohistochemistry; Male; Pancreatic Neoplasms/drug therapy; Pancreatic Neoplasms/enzymology; Survival Analysis; Gemcitabine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Deoxycytidine Kinase Type of study: Prognostic_studies Limits: Female / Humans / Male Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2006 Document type: Article Affiliation country: Italy Country of publication: United States

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