N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry.

Aguilar, Hector C; Matreyek, Kenneth A; Filone, Claire Marie; Hashimi, Sara T; Levroney, Ernest L; Negrete, Oscar A; Bertolotti-Ciarlet, Andrea; Choi, Daniel Y; McHardy, Ian; Fulcher, Jennifer A; Su, Stephen V; Wolf, Mike C; Kohatsu, Luciana; Baum, Linda G; Lee, Benhur

Aguilar, Hector C; Matreyek, Kenneth A; Filone, Claire Marie; Hashimi, Sara T; Levroney, Ernest L; Negrete, Oscar A; Bertolotti-Ciarlet, Andrea; Choi, Daniel Y; McHardy, Ian; Fulcher, Jennifer A; Su, Stephen V; Wolf, Mike C; Kohatsu, Luciana; Baum, Linda G; Lee, Benhur.

Affiliation

Aguilar HC; Department of MIMG, David Geffen Schoo; of Medicine at UCLA, Los Angeles, CA 90095, USA.

J Virol ; 80(10): 4878-89, 2006 May.

Article in En | MEDLINE | ID: mdl-16641279

Subject(s)

Membrane Fusion/physiology; Nipah Virus/physiology; Polysaccharides/physiology; Viral Envelope Proteins/physiology; Viral Fusion Proteins/physiology; Animals; Cell Line; Dogs; Glycosylation; HeLa Cells; Henipavirus Infections/prevention & control; Henipavirus Infections/virology; Humans; Membrane Fusion/genetics; Neutralization Tests; Nipah Virus/genetics; Nipah Virus/pathogenicity; Polysaccharides/genetics; Polysaccharides/metabolism; Viral Envelope Proteins/genetics; Viral Envelope Proteins/metabolism; Viral Fusion Proteins/biosynthesis; Viral Fusion Proteins/genetics; Viral Fusion Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polysaccharides / Viral Envelope Proteins / Viral Fusion Proteins / Nipah Virus / Membrane Fusion Limits: Animals / Humans Language: En Journal: J Virol Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States

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