Ischemia and reperfusion increases susceptibility to ventilator-induced lung injury in rats.
Am J Respir Crit Care Med
; 174(2): 178-86, 2006 Jul 15.
Article
in En
| MEDLINE
| ID: mdl-16645175
ABSTRACT
OBJECTIVES:
Hemorrhagic shock followed by resuscitation (HSR) commonly triggers an inflammatory response that leads to acute respiratory distress syndrome.HYPOTHESIS:
HSR exacerbates mechanical stress-induced lung injury by rendering the lung more susceptible to ventilator-induced lung injury.METHODS:
Rats were subjected to HSR, and were randomized into an HSR + high tidal volume and zero positive end-expiratory pressure (PEEP) or a HSR + low tidal volume with 5 cm H(2)O PEEP. A sham-operated rat + high tidal volume and zero PEEP served as a control.RESULTS:
HSR increased susceptibility to ventilator-induced lung injury as evidenced by an increase in lung elastance and the wet/dry ratio and a reduction in Pa(O(2)) as compared with the other groups. The lung injury observed in the HSR + high tidal volume group was associated with a higher level of interleukin 6 in the lung and blood, increased epithelial cell apoptosis in the kidney and small intestine villi, and a tendency toward high levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatinine in plasma.CONCLUSIONS:
HSR priming renders the lung and kidney more susceptible to mechanical ventilation-induced organ injury.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Reperfusion Injury
/
Ventilators, Mechanical
Type of study:
Etiology_studies
/
Evaluation_studies
Limits:
Animals
Language:
En
Journal:
Am J Respir Crit Care Med
Journal subject:
TERAPIA INTENSIVA
Year:
2006
Document type:
Article
Affiliation country:
Canada